Clinical Observations on the Use of Isoniazid in Tuberculosis

Autor: Payne, Howard M., Hackney, Robert L., Clark, Eugene A., Johnson, Preston C.
Zdroj: Diseases of the Chest; June 1954, Vol. 25 Issue: 6 p611-621, 11p
Abstrakt: 1)Isoniazid toxicity is observed more frequently at dosages above 6 mgs. per kilo but may occur at any level.2)Weight loss may be a symptom of isoniazid toxicity.3)Isoniazid stimulates neural activity and may accentuate autonomic tone or exaggerate the symptoms of neurotoxicity from streptomycin.4)Isoniazid has no direct effect upon blood sugar levels in normal or diabetic patients.5)Isoniazid may be given safely in doses of 200 to 236 mgs. intramuscularly without serious toxic or irritative effect. This may be done either alone or in combination with streptomycin.6)The intramuscular use of isoniazid-streptomycin combined is worthy of further study.
Databáze: Supplemental Index