| Autor: |
Forlano, A.J., Jarowski, C.I., Hammer, H.F. |
| Zdroj: |
Journal of Pharmaceutical Sciences; July 1968, Vol. 57 Issue: 7 p1184-1187, 4p |
| Abstrakt: |
A series of α,α-dialkyl substituted aliphatic esters of vitamin A was prepared. The stability of these compounds was compared with vitamin A palmitate in hydroalcoholic acidic media, alkaline media, and under oxidative conditions. In all cases steric hindrance on the α-carbon of the fatty acid group increased the stability of the esters in solution. Under oxidative conditions it appeared that a long aliphatic chain was necessary for maximal stability. These results indicate that an ester such as vitamin A α,α-dimethylpalmitate could demonstrate optimal stability under all the conditions examined. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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