| Autor: |
Repta, Arnold J., Robinson, Joseph R., Higuchi, Takeru |
| Zdroj: |
Journal of Pharmaceutical Sciences; November 1966, Vol. 55 Issue: 11 p1200-1204, 5p |
| Abstrakt: |
Earlier studies have shown that cyclic anhydrides, such as succinic, glutaric, etc., interact with citrate ions in aqueous solution to form what appears to be a citric anhydride species. These interactions have been assumed to be highly reversible through intermediate formation of a mixed anhydride. The present studies were concerned with a comparable system which was expected to be essentially irreversible. Spectrophotometric investigations have shown that acetic anhydride apparently reacts with citrate in aqueous solution to form a new species which undergoes rapid hydrolysis. The rate of the initial reaction and the rate of the subsequent step appear to depend on the citrate concentration and pH. Results of chroma-tographic studies on products obtained by reaction with aniline at different phases of the reaction are presented. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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