| Abstrakt: |
The treatment of infants from birth for convulsive disorders is hindered by the lack of a rapid method for monitoring anticonvulsant blood levels using a small volume of plasma. The method of Berlin et al. (1) for diphenylhydantoin was modified by Solow [1] for the simultaneous determination of multiple drug levels. However, this method has a fairly low extraction efficiency for primidone, a primary anticonvulsant. Kallberg et al. (2) reported a rapid method for phenobarbital which we found also yielded almost total recovery of diphenylhydantoin. However, the recovery of primidone again was extremely low (16%), and the aqueous solution of trhnethylphenylanilinium hydroxide, which was used for the final extraction, degraded phenobarbital to phenylethylmalonamide even at low injector temperatures (230°). |
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