| Abstrakt: |
The effect of (−)-∆9-trans-tetrahydrocannabinol (I) on latency to hindlimb tonic extension produced by maximal electroconvulsive shock was studied in mice following injection by four routes of administration: oral, subcutaneous, intraperitoneal, and intravenous. For each route, four different vehicles were used: bovine serum albumin, polysorbate 80, polyvinylpyrrolidone, and propylene glycol. The anticonvulsant effect of I was strongest in the propylene glycol vehicle with subcutaneous and intraperitoneal routes and equal in the propylene glycol and polyvinylpyrrolidone vehicles with the oral route. With these three routes, bovine serum albumin and saline appeared to be inadequate vehicles for studying the anticonvulsant activity of I. When the intravenous route was used, anticonvulsant activity of I was found with all four vehicles, with propylene glycol and polyvinylpyrrolidone allowing the greatest effect of I; however, the propylene glycol vehicle itself also showed anticonvulsant activity. A further experiment showed that the duration of action of I following oral administration was substantially longer in the propylene glycol than in the polyvinylpyrrolidone vehicle. |
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