| Autor: |
Ho, Beng T., McIsaac, William M., Wayne Tansey, L., Kralik, Patricia M. |
| Zdroj: |
Journal of Pharmaceutical Sciences; November 1968, Vol. 57 Issue: 11 p1998-2000, 3p |
| Abstrakt: |
Several N-acyltryptamines were found to inhibit hydroxyindole-O-methyltransferase. Of these inhibitors the most active was N-phenylacetyltryptamine, having an affinity to the enzyme six times greater than the substrate N-acetylserotonin. These studies showed that the alkyl and aralkyl groups of the amides were most likely complexed with the enzyme by hydrophobic bonding. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text