Antibacterial agents not presently employed as preservatives in ophthalmic preparations found effective against Pseudomonas aeruginosa

Autor: Kohn, S.R., Gershenfeld, Louis, Barr, Martin
Zdroj: Journal of Pharmaceutical Sciences; December 1963, Vol. 52 Issue: 12 p1126-1129, 4p
Abstrakt: Fifty‐one chemical substances, not heretofore employed as preservatives in ophthalmic solutions, were examined for their effectiveness as antibacterial agents against 13 different strains of Pseudomonas aeruginosa. In vitroand in vivomethods were employed. Eleven of these agents showed a satisfactory sterilizing time against these strains. Further study of the following is indicated to determine their practical use as effective preservatives in ophthalmic preparations: Intexsan LB, Intexsan MB, Dichloran, DMBC, Cetol, Arquad 16, Virac, Betadine, Biopal VRO, chlorhexidine, and colistin.
Databáze: Supplemental Index