| Autor: |
Haikala, Veikko E., Heimonen, Irma K., Vuorela, Heikki J. |
| Zdroj: |
Journal of Pharmaceutical Sciences; May 1991, Vol. 80 Issue: 5 p456-458, 3p |
| Abstrakt: |
A selective reversed-phase HPLC method for the determination of ibuprofen in different ointment bases is described. Following a simple dilution step, the drug was separated from interfering compounds on an octadecylsilica column protected by a precolumn. A mobile phase of aqueous tetrahydrofuran buffered by phosphate was used. Detection was monitored at 219 nm. After each 10 injections of lipophilic samples, the columns were washed with tetrahydrofuran and n-hexane. Recoveries of ibuprofen from a new pilot preparation spiked to contain 4,5, and 6% of the drug were 100.4,100.3, and 99.7%, respectively. The precision at each concentration was <0.8%. The analysis of ibuprofen degeneration products showed that the method also provides an indication of the stability of the drug. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text