In VitroStability of Sodium NitroprussideSolutions for Intravenous Administration

Autor: Mahony, Cheryl, Brown, James E., Stargel, W. Wayne, Verghese, Chacko P., Bjornsson, Thorir D.
Zdroj: Journal of Pharmaceutical Sciences; June 1984, Vol. 73 Issue: 6 p838-839, 2p
Abstrakt: A sensitive high-performance liquid chromatographic assay for nitroprusside using an ion-exchange column and UV detection was developed to evaluate the stability of aqueous solutions of sodium nitroprusside in light-protected glass and plastic containers and during simulated infusions. The results showed that sodium nitroprusside is stable in 5% dextrose, normal saline, and lactated Ringer's solutions in light-protected glass or plastic containers. In addition, there was no decrease in the delivered potency of sodium nitroprusside solutions during simulated infusions lasting up to 24h.
Databáze: Supplemental Index