| Autor: |
Anik, Shabbir T., McRae, Georgia, Nerenberg, Clinton, Worden, Ann, Foreman, Joann, Hwang, Jiin-Yu, Kushinsky, Stanley, Jones, Richard E., Vickery, Brian |
| Zdroj: |
Journal of Pharmaceutical Sciences; May 1984, Vol. 73 Issue: 5 p684-685, 2p |
| Abstrakt: |
Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys. Absorption was rapid and very reproducible, with peak levels occurring at 15–30 min and a bioavailability of ~2% relative to a subcutaneous dose. The nasal dose response was highly nonlinear. The nonlinearity was apparently associated with the absorption phase, since elimination profiles at all doses were similar. |
| Databáze: |
Supplemental Index |
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