| Autor: |
Baker, B.R., Lourens, Gerhardus J. |
| Zdroj: |
Journal of Pharmaceutical Sciences; July 1967, Vol. 56 Issue: 7 p871-875, 5p |
| Abstrakt: |
The relative binding to dihydrofolic reductase by 16 m-substituted 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazines—nine of which are newly synthesized— has been measured. Strong evidence is presented to indicate that the increased binding by terminal phenyl groups on a m-substituent is due to complexing to a relatively hydrophilic area since terminal benzyl and terminal phenoxy groups give nearly the same increments in binding. The possible conversion of such compounds to candidate active-site-directed irreversible inhibitors of dihydrofolic reductase is discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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