| Autor: |
Wainerx, Irving W., Doyle, Thomas D., Adams, William M. |
| Zdroj: |
Journal of Pharmaceutical Sciences; August 1984, Vol. 73 Issue: 8 p1162-1164, 3p |
| Abstrakt: |
A rapid and accurate method was developed for the determination of the enantiomeric composition of amphetamine preparations. Amide derivatives of the amphetamine enantiomers are first formed by using achiral 2-naphthoyl chloride. The resulting enantiomeric amides are then chromatographed on a commercially available chiral stationary phase. The capacity factors (k′) of (minus;)- and (+)-2-naphthoylamphetamine are 20 and 22, respectively, and the separation factor (α) for the two enantiomers is 1.08. The method allows detection of as little as 0.5% of the (minus;)-enantiomer in (+)-amphetamine and is applicable to both bulk drug and single-tablet analyses. |
| Databáze: |
Supplemental Index |
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