| Autor: |
Flynn, G.L., Yalkowsky, S.H., Weiner, N.D. |
| Zdroj: |
Journal of Pharmaceutical Sciences; February 1974, Vol. 63 Issue: 2 p300-304, 5p |
| Abstrakt: |
Sir:Previous publications (1–10) showed how the physicochemical properties of chemically and structurally related compounds, particularly homologs, can be the principal determinant of the structure–biological activity “parabolic” profile for a congeneric family by reason of the influence of the physicochemical properties on relative rates of transport. There are, of course, circumstances that preclude involvement of transport in the determination of activity profiles. Even in the absence of a significant or identifiable transport component, so-called “parabolic” dependencies are generally still observed for compounds chemically similar in polar functionality but widely dissimilar in hydrophobic property (11). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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