| Autor: |
Polli, Gerald P., Frost, Bettina M. |
| Zdroj: |
Journal of Pharmaceutical Sciences; December 1969, Vol. 58 Issue: 12 p1543-1544, 2p |
| Abstrakt: |
An investigation of the role of polyvinylpyrrolidone (PVP) as a stabilizer for hexylresorcinol in a compressed tablet was conducted and the effect of PVP on the microbiological activity of hexylresorcinol was investigated.The presence of PVP in the tablet was shown to be responsible for the color stability of the hexylresorcinol.A molecular interaction between hexylresorcinol and PVP, of unusually strong complexing tendency, was identified by the solubility isotherm method and by IR spectroscopy.The stoichiometry of the complex was calculated to be one hexylresorcinol molecule per vinylpyrrolidone repeating unit.The antimicrobial activity of hexylresorcinol was evaluated by two methods using both Gram-positive and Gram-negative bacteria, and was found to be reduced in the presence of PVP.This reduction in activity was apparently due to the molecular interaction between hexylresorcinol and PVP and, therefore, indicates a need for the biological evaluation of complexes whenever their formation is suspected. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text