Pharmacological Effects of Paniculatin—a Glycoside Isolated from Ipomoea DigitataLinn

Autor: Matin, M.A., Tewari, J.P., Kalani, D.K.
Zdroj: Journal of Pharmaceutical Sciences; June 1969, Vol. 58 Issue: 6 p757-759, 3p
Abstrakt: A glycoside (paniculatin), m.p. 134°, C30H54O13has been isolated from the tubers of Ipomoea digitataLinn. It elevated the blood pressure, showed a stimulant effect on myocardium and respiration, a vasoconstrictor and bronchoconstrictor effect, a spasmogenic effect on smooth muscles of gut, and also an oxytocic activity. The LD50(48 hr.), with 95% fiducial limits, was found to be 867.4 (755.3–985.1) mg./kg. (SE± 1.03) intraperitoneally in mice.
Databáze: Supplemental Index