| Abstrakt: |
Mixing benzalkonium chloride with urea provides an excellent means of obtaining a dry physical form of benzalkonium chloride suitable for tableting. Tablets containing benzalkonium chloride-urea admixtures, with and without antirust ingredients (sodium nitrite and sodium carbonate), were readily prepared using direct compression techniques. The tableting characteristics of the admixtures appear to be due to the formation of an adduct and not just the simple adsorption of benzalkonium chloride by urea. The tablets were evaluated under various stability conditions relative to changes in hardness, friability, dissolution rate, germicide content and activity, and anticorrosive action. Results indicated that the best tablets were those prepared using admixtures consisting of 1.5 to 2 parts urea to 1 part benzalkonium chloride. |
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