| Autor: |
Svoboda, Gordon H., Poore, Gerald A., Montfort, Marilyn L. |
| Zdroj: |
Journal of Pharmaceutical Sciences; October 1968, Vol. 57 Issue: 10 p1720-1725, 6p |
| Abstrakt: |
Inclusion in the authors' phytochemical screening program of plants of the family Apocynaceaerelated to Catharanthus roseusG. Don seemed logical in view of the success realized with the Madagascan periwinkle. Screening of the appropriate extracts of Ochrosia maculataelicited both oncolytic and neurosedative activities. The former was found to be associated with 9-methoxyellipticine, the latter with reserpine. While 9-methoxyellipticine possesses experimental antitumor activity of a somewhat lesser order than some of the available clinically active agents, it does exhibit a broader spectrum than most of these compounds. Its moderate degree of potency as an antitumor agent is expressed by its activity against several of the solid mouse neoplasms maintained in these laboratories. |
| Databáze: |
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