| Autor: |
Ardueser, Gloria A., Heim, Harold C. |
| Zdroj: |
Journal of Pharmaceutical Sciences; February 1967, Vol. 56 Issue: 2 p254-258, 5p |
| Abstrakt: |
Chloroquine at a concentration of 5.4 × 10−4M enhanced the oxygen consumption of rat ventricle homogenates respiring in the presence of succinate. This effect was not noted with aged homogenates. Total α-keto acids present after incubation of homogenates with succinate was observed to be diminished when chloroquine was present. The oxidation of malate and β-hydroxybutyrate was inhibited by the addition of chloroquine. Chronic poisoning by this drug did not affect the ability of heart homogenates to utilize β-hydroxybutyrate, but the oxidation of malate was impaired. A purified malic dehydrogenase was not inhibited by chloroquine but, at a concentration of 5.4 × 10−4M, the drug markedly inhibited the oxidation of NADH by a fragmented mitochondrial suspension prepared from rat myocardium. |
| Databáze: |
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