| Autor: |
Fois, Romano A., Ashley, John J. |
| Zdroj: |
Journal of Pharmaceutical Sciences; March 1991, Vol. 80 Issue: 3 p300-302, 3p |
| Abstrakt: |
To the Editor: The time for equilibration during equilibrium dialysis studies is often considered to limit the usefulness of the technique. It is therefore important to design these studies so that the time to equilibrium is minimized. On the basis of Fick’s law, the use of dialysis cells which have a high membrane surface area to volume ratio and choice of a membrane with a high diffusivity and low effective thickness can reduce the equilibration time. Øie and Guentert have described the time advantage to be gained by introducing the drug to the protein side, rather than the buffer side of the dialysis cell. Their treatment was expanded by McNamara and Bogardus who related the time (tδ)required for the concentration in the dialysate to reach a stated fraction (δ)away from the equilibrium concentration to the membrane transport rate constant (kT)and the fraction unbound (α)in the protein compartment (eq 1), when the drug is introduced initially into the protein compartment: |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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