Autor: |
Contractor, Avinash M., David Richman, M., Shangraw, Ralph F. |
Zdroj: |
Journal of Pharmaceutical Sciences; October 1970, Vol. 59 Issue: 10 p1488-1491, 4p |
Abstrakt: |
Dose variation in commercial meter valves appears to be within acceptable pharmaceutical limits. Changes in delivered dose weights were found to occur during container emptying due to formulation fractionation. A more serious problem results from failure of the meter chamber to fill uniformly when the container is almost empty (~15% remaining). Three valves were found to be superior to others in overcoming this problem. Storage position influenced drainback in meter valves, particularly at later stages of container emptying. |
Databáze: |
Supplemental Index |
Externí odkaz: |
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