Autor: |
Bagdon, Walter J., Mann, David E. |
Zdroj: |
Journal of Pharmaceutical Sciences; January 1965, Vol. 54 Issue: 1 p153-154, 2p |
Abstrakt: |
The intraperitoneal administration of promazine hydrochloride to albino mice at a dosage level of 1mg./Kg. of body weight caused hyperthermia in 10-day-old and hypothermia in 38-day-old animals. The removal of the chlorine atom from the structure of chlorpromazine decreased significantly the hyperthermic and hypothermic responses of the phenothiazine in immature and mature mice, respectively. No significant difference due to sex was noted in the activity of the drug at different ages. |
Databáze: |
Supplemental Index |
Externí odkaz: |
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