| Autor: |
Storz, Gunther K., DeKay, H. George, Banker, Gilbert S. |
| Zdroj: |
Journal of Pharmaceutical Sciences; January 1965, Vol. 54 Issue: 1 p85-91, 7p |
| Abstrakt: |
The rheological investigation of a series of aqueous cellulose polymer (carboxymethylhydroxyethylcellulose)-polyhydroxyl compound (polyethylene glycol) systems showed large increases in η' (indicator of viscosity) as determined using the power law equation (η'=FN/G). These increases were most predominant when the lower molecular weight polyethylene glycols were evaluated with CMHEC. A computer program was written using Fortran for the IBM 7090/1401 computer system for solution of the power law equation and determination of regression coefficients. Certain of these CMHEC-polyethylene glycol systems were used as vehicles in preparing 10 per cent suspensions containing either zinc oxide or sulfamerazine calcomites. Superior suspension stability was noted for both insoluble drugs in the interacted systems with little or no phase separation and no caking occurring in a 120-day observation period. |
| Databáze: |
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