| Autor: |
Venturella, Vincent S., Bianculli, J.A., Sager, R.W. |
| Zdroj: |
Journal of Pharmaceutical Sciences; February 1963, Vol. 52 Issue: 2 p142-146, 5p |
| Abstrakt: |
Several derivatives of 2-hydroxypyrazine were prepared containing a phenylcarbinol moiety in the 3-position. A method was developed to prepare these compounds in order to test the efficacy of the basic cyclization reaction between a bifunctional α-amino amide and several 1,2-dicarbonyls. The synthetic method used necessitated some study of the chemistry of threo-β-phenylserine and its amide. After many unsuccessful experiments, it was found that the amide of this acid is best prepared through the use of the N-carbobentoxy methyl ester. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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