| Autor: |
Remmers, Edward G., Barringer, William C., Sieger, George M., Doerschuk, Albert P. |
| Zdroj: |
Journal of Pharmaceutical Sciences; December 1964, Vol. 53 Issue: 12 p1452-1456, 5p |
| Abstrakt: |
Metal-acid complexes with a number of members of the tetracycline family have been prepared for chemical and biological evaluation. The studies reported here indicate that these preparations exhibited properties not displayed by the uncomplexed antibiotic. The most interesting properties characteristic of selected complexes in this series include enhanced solubility at pH 4.0–7.0, enhanced alkaline stability, reduced acute toxicity, reduced tissue irritation and rapid tissue diffusion, and enhanced blood levels. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text