| Abstrakt: |
Ether extracts of urine from patients treated with mitotane (o,p'-DDD) were methylated with diazomethane. Five derivatives of metabolites were detected and identified by comparison of GLC retention times, mass spectra, and IR spectra with synthetic reference compounds. The derivatives are: methyl o,p'- dichlorodiphenylacetate, methyl l-(2-chloro-4-methoxyphenyl)-l-(4-chlorophenyl)acetate, methyl l-(2-chloro-3-methoxyphenyl)-l-(4-chlorophenyl)acetate, methyl l-(2-chloro-3,4-dimethoxy)-l-(4-chlorophenyl)acetate, and o,p'-dichlorodiphenyl- acetylglycine methyl ester. The synthesis and mass, IR, and NMR spectra of reference compounds are given. Metabolite levels over a period of time in urine samples of two patients were quantitated by GLC. |
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