| Autor: |
Ullah, Ismat, Cadwallader, Donald E. |
| Zdroj: |
Journal of Pharmaceutical Sciences; February 1971, Vol. 60 Issue: 2 p230-233, 4p |
| Abstrakt: |
Dissolution studies were carried out on micronized and regular milled griseofulvin powders. A three-compartment dissolution apparatus previously developed by the authors was used. A barrier was used in the dissolution medium to prevent the floating masses from entering directly into the sink phase. The individual, wetted particles of these powders could pass through the barrier pores. It was demonstrated that these particles do not enter and dissolve in the sink phase due to the presence of the aqueous layer around them. The presence of a sink phase and the introduction of samples in the form of suspensions were considered necessary to obtain appropriate rank order in the dissolution rates. A modified Hixon and Crowell cube root law was applied to obtain dissolution-rate constants for two different particle-size griseofulvin powders. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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