| Autor: |
Iuliucci, John D., Gautieri, Ronald F. |
| Zdroj: |
Journal of Pharmaceutical Sciences; March 1971, Vol. 60 Issue: 3 p420-425, 6p |
| Abstrakt: |
The results of this investigation indicate that teratogenic effects of high subcutaneous doses of morphine sulfate administered on Day 8 or 9 of gestation in CF-1 mice are not augmented by histamine dihydrochloride or decreased by diphenhydramine. On the contrary, histamine caused a decrease in the incidence of exencephaly and cryptorchid testes and diphenhydramine caused an enhancement of the teratogenic response when both of these agents were used in combination with morphine sulfate. |
| Databáze: |
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