| Autor: |
Anderson, Paula J., Zhou, Xiang, Breen, Phil, Gann, Larry, Logsdon, Todd W., Compadre, Cesar M., Charles Hiller, F. |
| Zdroj: |
Journal of Pharmaceutical Sciences; July 1998, Vol. 87 Issue: 7 p841-844, 4p |
| Abstrakt: |
The pharmacokinetics of inhaled (R,S)-albuterol following pulmonary absorption were studied in healthy human subjects. Ten subjects (5 females and 5 males) inhaled two puffs (180μg) of albuterol via a metered-dose inhaler and spacer device. All subjects were nonsmoking and had normal pulmonary function. Charcoal slurries were ingested to block gastrointestinal absorption of drug. Venous samples were obtained from each subject at thirteen time points from 0 through 12h post dose. (R,S)-Albuterol concentration in plasma was measured using a gas chromatography–mass spectrometry (GC-MS) assay. The plasma concentration–time profiles conformed to a two-compartment extravascular model with first-order absorption kinetics. The drug levels reached maximum in 12.6±2.2 (SD) minutes, which is in contrast with previous reports that maximum plasma concentrations occur within 2 to 4h. The mean peak plasma level was 1469±410pg/mL. The mean half-life of distribution was 17.9±8.2min. The mean half-life of elimination was 4.4±1.5h. Female subjects achieved peak concentration more rapidly than male subjects (10.4 vs 14.8min, p=0.01) and had a higher mean peak concentration (1778 vs 1159pg/mL, p=0.04). |
| Databáze: |
Supplemental Index |
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