| Autor: |
Mezei, M., Sager, R.W., Stewart, W.D., Deruyter, A.L. |
| Zdroj: |
Journal of Pharmaceutical Sciences; June 1966, Vol. 55 Issue: 6 p584-590, 7p |
| Abstrakt: |
Nonionic surface-active agents were applied to rabbit skin daily in an attempt to determine the physiological properties and irritative potential of some seleted surfactants. Three methods of evaluation were used: gross examination, microscopical examination, and measurement of the respiratory metabolic activity of the treated skin. The gross and microscopical evaluations of these tests both indicated that the greatest irritation was produced by the polyoxyethylene ethers. These substances produced gross inflammation in even short periods of time (3days) in the weakest dilutions (1 per cent) in which they were tested. Polysorbates caused more irritation than sorbitans. The metabolic measurements indicated a two, three, and fourfold increase in the oxygen consumption of the inflamed, treated skin sample, depending on the length of the treatment and the type of agent used. |
| Databáze: |
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