| Autor: |
Ehrsson, Hans, Lönroth, Ulla |
| Zdroj: |
Journal of Pharmaceutical Sciences; July 1982, Vol. 71 Issue: 7 p826-827, 2p |
| Abstrakt: |
The protein binding and degradation rate of melphalan in human albumin solutions and plasma have been investigated. In plasma, melphalan is bound 69.0 ± 3.4% (25°, melphalan concentration 25 μg/ml). The stability of melphalan when bound to albumin is about three times higher (k =3.07 × 10–2± 0.48 × 10–2hr–1) than unbound in solution (k= 1.14 × 10–1± 0.01 hr–1). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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