| Autor: |
Tomarelli, R.M., Dougherty, T.M., Bernhart, F.W. |
| Zdroj: |
Journal of Pharmaceutical Sciences; December 1966, Vol. 55 Issue: 12 p1392-1395, 4p |
| Abstrakt: |
The hypocholesterolemic activity of a number of natural and synthetic steroids was determined in a 3-day oral assay using male rats with hypercholesterolemia of dietary origin. The reduction in serum cholesterol was linearly related to the log dose of the administered natural or modified estrogen; the effect was evident 6hr. after oral administration and had reached a maximum in 24 to 30hr. Active steroids lowered the elevated serum phospholipids, cholesterol/phospholipid ratios, triglycerides, αand βlipoproteins, and β/αlipoprotein ratios, but not the elevated serum globulins. The effect of the steroids on body weight permitted a semiquantitative estimation of feminizing activity. |
| Databáze: |
Supplemental Index |
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