Sterically Hindered Esters of Vitamin A II: Vitamin A α,α-Dimethylpalmitate

Autor: Forlano, A.J., Jarowski, C.I., Hammer, H.F., Merritt, E.G.
Zdroj: Journal of Pharmaceutical Sciences; January 1970, Vol. 59 Issue: 1 p121-123, 3p
Abstrakt: A previous study showed that short-chain sterically hindered esters of vitamin A demonstrated better stability in solution than the commercial plamitate. The oxidative stability of the short-chain sterically hindered esters, however, was poor. This work indicated that a long aliphatic chain with steric hindrance in the α-position was necessary for maximal stability. A compound of this type, vitamin A α,α-dimethylpalmitate, was prepared and evaluated.
Databáze: Supplemental Index