| Autor: |
Clemente, Emmett, de Paul Lynch, Vincent |
| Zdroj: |
Journal of Pharmaceutical Sciences; January 1968, Vol. 57 Issue: 1 p72-78, 7p |
| Abstrakt: |
Mescaline (TMPEA) elicited a motor response (dependent upon segment and concentration) from isolated guinea pig, rat, and cat ileum. It did not alter inotropic or chronotropic activity of isolated mammalian atria. Estrogen dominated uteri responded similarly. TMPEA antagonized serotonin-induced motor responses of rat and guinea pig uteri. High concentrations of ganglionic blocking agents potentiated TMPEA motor effects. Evidence suggests that TMPEA does not act viaa cholinergic mechanism, but rather through catecholamine mechanisms. The end result varies in definite situations. The primary site of action of TMPEA appears to be at the α-adrenergic receptor site. |
| Databáze: |
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