| Autor: |
Sangekar, S.A., Sarli, M., Sheth, P.R. |
| Zdroj: |
Journal of Pharmaceutical Sciences; June 1972, Vol. 61 Issue: 6 p939-944, 6p |
| Abstrakt: |
Twenty-four formulations of placebo tablets, made from eight excipients for direct compression and three disintegrants, were evaluated under various conditions of relative humidity. The data were evaluated statistically so that the formulations could be given a relative ranking on the basis of maximum hardness, minimum change of disintegration time, minimum moisture uptake, and minimum change in volume. The three preferred direct compression formulations in order of overall performance were: (a) dibasic calcium phosphate dihydrate-starch USP, (b) lactose hydrous beadlets-direct compression starch, and (c) lactose anhydrous DTG-starch USP. Mannitol appears to be the best sugar for direct compression chewable tablet formulations. |
| Databáze: |
Supplemental Index |
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