| Abstrakt: |
Three active ingredients in liquid antitussive preparations, acetaminophen, chlorpheniramine maleate, and dextromethorphan hydrobromide, were separated by high-speed liquid chromatography on an octadecylsilane (permanently bonded to a controlled surface porosity support) column with a buffered, pH 8.8, alcohol-water mobile phase and measured with a UV photometer. Due to the relatively large excess of acetaminophen and the fixed detector wavelength (254 nm), the analysis was performed sequentially in two steps. Nonetheless, results were obtained in one-third the time required for conventional methods and instrument flexibility was maintained, thereby permitting its use for a variety of analyses. The relative standard deviations for the three components were 1.8, 0.76, and 2.0%, respectively. |
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