| Autor: |
Ithakissios, Dionyssis S., Kessler, Wayne V., Arvesen, James N., Born, Gordon S. |
| Zdroj: |
Journal of Pharmaceutical Sciences; January 1974, Vol. 63 Issue: 1 p146-149, 4p |
| Abstrakt: |
The effect of multiple doses of cadmium on carbohydrate metabolism in rats was studied. The treated groups received two dose levels, 0.25 and 0.50mg cadmium/kg ip every 2nd day for 20 doses. Plasma glucose, immunoresponsive insulin levels, and body weights were determined before treatment and after 10 and 20 doses of cadmium. After the last dosage, D-glucose-14C (uniformly labeled) was administered to a randomly chosen subgroup and a carbon dioxide radiorespirometry experiment was performed. Statistically significant differences in blood glucose and insulin levels were not detected at any time, indicating no effect of cadmium on the pancreatic secretory activity. There was no effect on body weights. However, cadmium increased the evolution of respiratory 14CO2. It is postulated that cadmium affects the rate of glucose metabolism in vivoby affecting mechanisms such as glycolysis and the tricarboxylic acid cycle. |
| Databáze: |
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