| Abstrakt: |
The hemolytic behavior of human erythrocytes in water-monohydric alcohol solutions was investigated. Complete hemolysis of erythrocytes occurred in all methanol, ethanol, n-propanol, and isopropanol solutions. Sodium chloride was effective in preventing complete hemolysis in solutions containing up to 18% methanol, 11% ethanol, 4% n-propanol, and 8% isopropanol. The addition of sodium chloride to solutions containing more than these concentrations of alcohol did not prevent hemolysis, discoloration, and/or precipitation of human red blood cells. The addition of 2% sodium chloride did not appreciably influence the hemolytic action of methanol, ethanol, n-propanol, or isopropanol, while 5% sodium chloride lowered the alcohol concentrations needed to cause 100% hemolysis. The data were used to calculate Van't Hoff ivalues for sodium chloride in the various alcohol solutions. Studies in aqueous ternary systems containing two alcohols (in 1:1 proportion) indicated an additive effect for the hemolytic action of alcohols. |
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