| Autor: |
Urbanyi, Tibor, Walter, Armin |
| Zdroj: |
Journal of Pharmaceutical Sciences; November 1971, Vol. 60 Issue: 11 p1699-1701, 3p |
| Abstrakt: |
A sensitive quantitative IR absorption method was developed for the determination of dicyandiamide as an impurity in a pharmaceutical preparation. This method is suitable for the determination of dicyandiamide in very low concentrations in insoluble guanidines and for the quantitative detection of dicyandiamide in many other compounds. The method is based on the determination of the nitrile stretching vibration in the region of 2200cm.−1. Although dicyandiamide forms as a by-product in an alkaline solution from the excess of cyanamide used in the reaction, the proposed method utilizes the separation of cyanamide and dicyandiamide by a simple extraction procedure, using methylene chloride and 2-ethoxyethanol as solvents. The sensitivity of the method was improved by using an internal standard technique. The superiority of this method over existing methods is discussed, along with the importance and usefulness of IR absorption, particularly in everyday pharmaceutical analysis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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