| Autor: |
Glamkowski, Edward J., Reitano, Philip A., Woodward, David L. |
| Zdroj: |
Journal of Pharmaceutical Sciences; December 1978, Vol. 67 Issue: 12 p1773-1774, 2p |
| Abstrakt: |
A series of 3-substituted l-[4-(2-indol-3-ylethyl)piperazinyljureas was synthesized and screened for antihypertensive activity in spontaneously hypertensive rats. Two compounds with aryl urea substituents were very potent and lowered blood pressure 55mm or more at oral doses of 100mg/kg. However, both compounds failed to produce a cardiovascular response in the normotensive dog. |
| Databáze: |
Supplemental Index |
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