| Autor: |
Richheimer, Steven L., Amer, Tahani M. |
| Zdroj: |
Journal of Pharmaceutical Sciences; November 1983, Vol. 72 Issue: 11 p1349-1351, 3p |
| Abstrakt: |
A reverse-phase high-performance liquid chromatographic (HPLC) method for determining sodium levothyroxine in tablet formulations is described. The sodium levothyroxine was extracted from tablets using a mobile phase consisting of 60% acetonitrile and 40% aqueous buffer. After centrifugation 200μl of the solution was chromatographed on a 10-μm C18column. The method gave accurate results when tested against the USP method, by the standard additions method, and by the spiked-placebo method. The method can also be used to determine content uniformity and dissolution of sodium levothyroxine tablets. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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