Differential Pulse Polarographic Determination of Submicrogram Quantities of Carmustine and Related Compounds in Biological Samples

Autor: Bartošek, Ivan, Daniel, Sonia, Sykora, Stanislav
Zdroj: Journal of Pharmaceutical Sciences; August 1978, Vol. 67 Issue: 8 p1160-1163, 4p
Abstrakt: A polarographic method was developed to determine the antineoplastic agent carmustine and other nitrosoureas, such as N-methyl-N-nitrosourea and N-cyclohexyl-N-nitrosourea, in biological fluids at levels well below 1μg/ml or g. The stability of carmustine in different media was investigated to prevent losses during administration or assay. Examples of nitrosourea determination in biological samples are given.
Databáze: Supplemental Index