| Autor: |
Ringhand, H.Paul, Ritschel, Wolfgang A. |
| Zdroj: |
Journal of Pharmaceutical Sciences; November 1979, Vol. 68 Issue: 11 p1461-1463, 3p |
| Abstrakt: |
A high-pressure liquid chromatographic procedure was developed for the determination of propylthlouracil in plasma. The method utilizes a reversed-phase C18chromatographic column and UV detection at 280nm. The method is sufficiently sensitive for most bioavailability and pharmacokinetic studies. Concentrations between 0.1 and 5.0 μg/ml were measured with a coefficient of variation of 0.6-5.3% for a given day. Methylthiouracil was employed as an internal standard. |
| Databáze: |
Supplemental Index |
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