| Autor: |
Skierkowski, Paul, Eisohly, Mahmoud A., Harland, Ernest C., King, Barbara S., Murphy, James C., Watson, E.S. |
| Zdroj: |
Journal of Pharmaceutical Sciences; July 1981, Vol. 70 Issue: 7 p829-830, 2p |
| Abstrakt: |
Tritium-labeled 3-n-pentadecylcatechol and its diacetate ester were fed to Sprague-Dawley rats. Both compounds were dissolved in ethanol and in corn oil vehicles and administered by gavage. The rats were placed in metabolic cages, and the urine and feces were collected. The radioactivity excreted in the urine and feces was determined by liquid scintillation counting, and the percentage of the administered dose was utilized as a measure of absorption. While there was no difference between the absorption of either compound, absorption was affected by the vehicle. Approximately 30% of the administered radioactivity appeared in the urine when ethanol was the vehicle, but about half that amount (14%) was excreted in the urine when the compounds were dissolved in corn oil. A subsequent bile cannulation study showed that the balance of the radioactivity found in the feces was not a result of biliary excretion. The majority of the activity recovered from urine and feces was eliminated within 48hr after dosing. These data indicate that oil is a poor vehicle for GI absorption of urushiol components. |
| Databáze: |
Supplemental Index |
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