Utility of Chloranil in Assay of Naphazoline, Clemizole,Penicillin G Sodium, and Piperazine

Autor: Belal, Saied, Elsayedx, M.Abdel-Hady, Abdel-Hamid, Mohamed E., Abdine, Hassan
Zdroj: Journal of Pharmaceutical Sciences; February 1981, Vol. 70 Issue: 2 p127-130, 4p
Abstrakt: A simple and sensitive spectrophotometric method is described for the assay of naphazoline, clemizole, penicillin G sodium, and piperazine. The method was based on the formation of a charge transfer complex between these drugs as n-donors and chloranil, the π-acceptor. Conformity to Beer's law enabled the assay of dosage forms of these drugs. Compared with official methods, the results obtained were of equal accuracy. A more detailed investigation of the naphazoline—chloranil complex was made with respect to its composition, association constant, and free energy change.
Databáze: Supplemental Index