High-Pressure Liquid Chromatographic Determination of Viloxazine in Human Plasma and Urine

Autor: Gillilan, Roberta, Masonx, William D.
Zdroj: Journal of Pharmaceutical Sciences; February 1981, Vol. 70 Issue: 2 p220-221, 2p
Abstrakt: A rapid, specific, high-pressure liquid chromatographic method is presented for the determination of viloxazine in plasma and urine. This method employs the high sensitivity of fluorescence detection with selective extraction and reversed-phase chromatography to measure concentrations as low as 25 ng/ml of plasma and 1.0 μg/ml of urine. Known metabolites of viloxazine do not interfere with the analysis, and experience with several hundred samples in a bioavailability study demonstrated the applicability and reliability of the method.
Databáze: Supplemental Index