GLC Analysis of Trifluoperazine in Human Plasma

Autor: Javaid, J.I., Dekirmenjian, H., Davis, J.M.
Zdroj: Journal of Pharmaceutical Sciences; January 1982, Vol. 71 Issue: 1 p63-66, 4p
Abstrakt: This report describes a sensitive gas chromatographic procedure for the measurement of trifluoperazine in human plasma. Trifluoperazine was extracted into heptane-2-propanol by a two-step-procedure and analyzed directly without derivatization. Prochlorperazine was employed as an internal standard because its structural and extraction characteristics were similar to trifluoperazine. The use of a nitrogen detection system reduced the number of interfering peaks. The within-day coefficient of variation in the method, over a 0.2–20-ng/ml concentration range was 9.4%.
Databáze: Supplemental Index