| Autor: |
Kelley, Michael J., Linnoila, R. Ilona, Avis, Ingalill L., Georgiadis, Mark S., Cuttitta, Frank, Mulshine, James L., Johnson, Bruce E. |
| Zdroj: |
Chest; July 1997, Vol. 112 Issue: 1 p256-261, 6p |
| Abstrakt: |
Small cell lung cancer (SCLC) cells express and secrete gastrin-releasing peptide (GRP) which binds to receptors and stimulates growth of these cells. A murine monoclonal antibody, 2A11, which binds GRP with high affinity, decreased growth of SCLC cells in vitroand in athymic nude mice. A phase 1 trial and pharmacokinetic modeling in patients with lung cancer has defined the phase 2 dose of 2A11 but the antitumor activity in patients is unknown. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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