Decomposition of α‐Hydroxyaryl Ketones and Characterization of Some Unusual Products

Autor: Gala, Dinesh, Puar, Mohindar S., Das, Pradip R., Kugelman, Max, Dibenedetto, Donald J.
Zdroj: Journal of Pharmaceutical Sciences; December 1992, Vol. 81 Issue: 12 p1199-1203, 5p
Abstrakt: α‐Hydroxyaryl ketones such as 2‐hydroxypropiophenone and 1‐(2,4‐difluorophenyl)‐2‐hydroxy‐1‐propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formation of the products are discussed.
Databáze: Supplemental Index