Solid Dispersions of Testosterone with Reduced Presystemic Inactivation

Autor: Babar, Almas, Jarowski, C.I.
Zdroj: Journal of Pharmaceutical Sciences; June 1983, Vol. 72 Issue: 6 p708-710, 3p
Abstrakt: Dissolution rates of solid dispersions of testosterone in various lipids or polyethylene glycol 6000 with and without surfactants were determined. In a limited study, selected dispersions were evaluated for oral absorption efficiency in a 32-year-old male. Significant reductions in urinary testosterone metabolites to testosterone ratios were observed with a 1:4 weight ratio of testosterone–polyethylene glycol 6000 and a 1:4:0.25 weight ratio of testosterone–cholesteryl stearate–sorbitan monolaurate.
Databáze: Supplemental Index