| Autor: |
Schatz, Michael, Zeiger, Robert S., Hoffman, Clement P., Harden, Kathleen M., Forsythe, Alan B., Chilingar, Linda M., Porreco, Richard P., Saunders, Brian S., Sperling, William L., Benenson, Abram S. |
| Zdroj: |
Chest; August 1990, Vol. 98 Issue: 2 p389-392, 4p |
| Abstrakt: |
Asthmatic mothers have been reported to deliver infants of lower mean birth weight than nonasthmatic mothers. This study examined the relationship between intrauterine growth and serial gestational spirometry in 352 pregnant asthmatic women who were prospectively treated and observed during pregnancy. A small (r = 0.11) but significant (p<0.04) direct correlation was demonstrated between infant birth weight and individual mean percent predicted FEV1during pregnancy. In addition, lower maternal mean FEV1during pregnancy was associated with increased incidences of birth weight in the lower quartile of the infant population (p = 0.002) and ponderal indices <2.2 (suggestive of asymmetric intrauterine growth retardation) (p<0.05), but not with increased incidences of preterm (<38 weeks) or low birth weight (<2,500 g) infants. Although lower mean birth weight occurred in infants of smoking compared with nonsmoking asthmatic mothers (p<0.02), the relationships of lower FEV1to birth weight in the lower quartile of the population (odds ratio 3.0, p = 0.002) and ponderal indices <2.2 (odds ratio 2.8, p<0.05) were shown by multivariate analysis to be above and beyond the influence of smoking and also independent of the effects of age, parity, acute asthmatic episodes, and asthma medications. These data support the hypothesis that lower maternal gestational FEV1during pregnancy is related to intrauterine growth retardation and suggest that the goals of gestational asthma therapy should include optimization of pulmonary function in addition to achievement of symptomatic control. |
| Databáze: |
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